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KMID : 0369820160460030205
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Jorunal of Korean Pharmaceutical Sciences
2016 Volume.46 No. 3 p.205 ~ p.220
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Cell penetrating peptides as an innovative approach for drug delivery; then, present and the future
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Bashyal Santosh
Noh Gyu-Bin
Keum Tae-Kwang
Choi Young-Wook
Lee Sang-Kil
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Abstract
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With the rapid development of biotechnology, various macromolecules as therapeutic agents have made drug delivery an important field of research. However, these are being commercialized as injection form. Due to low patient compliance, various non-invasive routes emerge as a promising strategy. Cell penetrating peptides (CPPs) have shown to assist in efficient and non-toxic manner. They provide ample evidence to deliver of many cargoes ranging from small molecules to proteins and even nanocarriers for various applications. This review briefly discusses about introduction of CPPs, history, cellular uptake mechanisms and various possible alternative routes for CPP-conjugated drug delivery system. It also aims to give a perspective on present status of CPP-mediated research, clinical development, possible obstacles as well as future opportunities. Thus, development of novel CPPs that are safe, tissue-specific and highly efficient will be exemplified and become ideal vehicles for therapeutic delivery in near future.
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KEYWORD
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Non-invasive delivery, Cell penetrating peptides, Cellular uptake, Cationic CPPs, Amphipathic CPPs, Covalent and non-covalent conjugation
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